5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one hydrate
Baicalein
CAS: 491-67-8;27462-75-5
Molecular Formula: C15H10O5
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one hydrate - Names and Identifiers
| Name | Baicalein |
| Synonyms | Noroxylin Baicalein Baicelein Baicaleine 5,6,7-Trihydroxyflavone BAICALEIN(SH)NOW RG GRADE 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one 5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one 5,6,7-trihydroxy-2-phenyl-4-chromenone hydrate 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one hydrate Baicalein, monohydrate, 5,6,7-Trihydroxy-2-phenyl-4H-chromen-4-one monohydrate |
| CAS | 491-67-8 27462-75-5 |
| EINECS | 000-000-0 |
| InChI | InChI=1/C15H10O5.H2O/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12;/h1-7,17-19H;1H2 |
| InChIKey | FXNFHKRTJBSTCS-UHFFFAOYSA-N |
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one hydrate - Physico-chemical Properties
| Molecular Formula | C15H10O5 |
| Molar Mass | 270.24 |
| Density | 1.3280 (rough estimate) |
| Melting Point | 256-271 °C (lit.) |
| Boling Point | 373.35°C (rough estimate) |
| Specific Rotation(α) | -14°(water)；-139°(pyridine) |
| Flash Point | 347°C |
| Solubility | Soluble in methanol, ethanol, acetone, ethyl acetate and hot glacial acetic acid, slightly soluble in chloroform, soluble in dilute sodium hydroxide is green brown, but unstable, easy to oxidize to green. |
| Vapor Presure | 8.55E-18mmHg at 25°C |
| Appearance | Yellow needle crystal (ethanol) |
| Color | Yellow or yellow-green |
| Merck | 14,942 |
| BRN | 272683 |
| pKa | 6.31±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week. |
| Sensitive | Sensitive to light and heat |
| Refractive Index | 1.5000 (estimate) |
| MDL | MFCD00017459 |
| Physical and Chemical Properties | Yellow prismatic crystals (from ethanol). Melting point 264~265 °c (decomposition). Soluble in ethanol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, slightly soluble in chloroform and nitrobenzene, almost insoluble in water, soluble in dilute sodium hydroxide green Brown, concentrated sulfuric acid yellow and green fluorescence. It can also be synthesized chemically in the root of Scutellaria baicalensis Georgi, and in the seed and stem bark of the echinaceae plant xylem indicum (L.)Vent. |
| Use | With anti-inflammatory, anti-allergic, diuretic, choleretic, cholesterol-lowering, anti-thrombosis, relieve asthma and other effects. It is also a specific inhibitor of mammalian liver salivary enzymes and has a role in the regulation of certain diseases. Industrial raw materials for the preparation of baicalin original phosphate for allergy, asthmatic Pneumonia, also as astringent, hemostatic. |
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one hydrate - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DJ3100898 |
| HS Code | 29329990 |
| Hazard Note | Irritant |
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one hydrate - Reference Information
| pharmacological activity | baicalein, also known as baicalin yuan, is an important pharmacodynamic active ingredient in traditional Chinese medicine scutellaria baicalensis (ScutellariabaicalensisGeorge) and wood butterfly (Oroxylumindicum), with significant antioxidant, anti-inflammatory, anti-allergic, antibacterial, antiviral, anti-tumor and other pharmacological activities. |
| Biological activity | Baicalein are CYP2C9 and prolyl endopeptidase inhibitors. |
| Target | Value |
| Uses | A flavonoid compound that is a xanthine oxidase inhibitor. It has anti-inflammatory, anti-allergic, diuretic, choleretic, cholesterol-lowering, anti-thrombosis, and asthma relief. It is also a specific inhibitor of salivary enzymes in mammalian liver, which has the effect of regulating certain diseases. In industry, baicalin protophosphate is prepared from it as a raw material for allergies and asthmatic pneumonia, as well as astringents and hemostatic drugs. |
| production method | 1. extract scutellaria baicalensis root, pulverize and boil with water for 3 times, combine the extracts, add acid to adjust the ph value to 4 after filtration, stir with slight heat, stand still, centrifuge to separate the precipitate. The sediment is washed with water with a ph of 4 and dried to produce crude products. The crude product is refluxed and hydrolyzed in 1.2?mol · L-1 hydrochloric acid with boiling water for several hours, and the precipitated product is scutellarin by cooling and filtering. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: Baicalein Request for quotationCAS: 491-67-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Baicalein Request for quotation
CAS: 491-67-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 491-67-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Baicalein Visit Supplier Webpage Request for quotationCAS: 491-67-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Baicalein Visit Supplier Webpage Request for quotationCAS: 491-67-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: Cyclovirobuxine Visit Supplier Webpage Request for quotationCAS: 860-79-1
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
Spot supply
Product Name: Baicalein Request for quotationCAS: 491-67-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Baicalein Request for quotation
CAS: 491-67-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 491-67-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Baicalein Visit Supplier Webpage Request for quotationCAS: 491-67-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Baicalein Visit Supplier Webpage Request for quotationCAS: 491-67-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: Cyclovirobuxine Visit Supplier Webpage Request for quotationCAS: 860-79-1
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
View History